Steroids and COVID-19: We Need a Precision Approach, Not One Size Fits All.
Identifieur interne : 000576 ( Main/Exploration ); précédent : 000575; suivant : 000577Steroids and COVID-19: We Need a Precision Approach, Not One Size Fits All.
Auteurs : Grant W. Waterer [Australie, États-Unis] ; Jordi Rello [Espagne, France]Source :
- Infectious diseases and therapy [ 2193-8229 ] ; 2020.
Abstract
COVID-19 is a new infectious disease causing severe respiratory failure and death for which optimal treatment is currently unclear. Many therapies have been proven to be ineffective; however, promising findings related to corticosteroid therapy have been published. Analysis of published data including in this issue suggests that therapy with corticosteroids in the range of 6 mg of dexamethasone (or equivalent) per day likely has a positive effect in patients requiring mechanical ventilation but there remains considerable doubt in patients over the age of 70, in patients with diabetes and patients with milder disease. Clinicians must consider the individual potential risks and benefits of corticosteroid in patients with COVID-19 rather than routinely using them until more data is available.
DOI: 10.1007/s40121-020-00338-x
PubMed: 32953385
PubMed Central: PMC7492684
Affiliations:
- Australie, Espagne, France, États-Unis
- Catalogne, Communauté de Madrid, Illinois, Languedoc-Roussillon, Occitanie (région administrative)
- Barcelone, Madrid, Nîmes
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Many therapies have been proven to be ineffective; however, promising findings related to corticosteroid therapy have been published. Analysis of published data including in this issue suggests that therapy with corticosteroids in the range of 6 mg of dexamethasone (or equivalent) per day likely has a positive effect in patients requiring mechanical ventilation but there remains considerable doubt in patients over the age of 70, in patients with diabetes and patients with milder disease. Clinicians must consider the individual potential risks and benefits of corticosteroid in patients with COVID-19 rather than routinely using them until more data is available.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32953385</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2193-8229</ISSN><JournalIssue CitedMedium="Print"><PubDate><Year>2020</Year><Month>Sep</Month><Day>16</Day></PubDate></JournalIssue><Title>Infectious diseases and therapy</Title><ISOAbbreviation>Infect Dis Ther</ISOAbbreviation></Journal><ArticleTitle>Steroids and COVID-19: We Need a Precision Approach, Not One Size Fits All.</ArticleTitle><Pagination><MedlinePgn>1-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s40121-020-00338-x</ELocationID><Abstract><AbstractText>COVID-19 is a new infectious disease causing severe respiratory failure and death for which optimal treatment is currently unclear. Many therapies have been proven to be ineffective; however, promising findings related to corticosteroid therapy have been published. Analysis of published data including in this issue suggests that therapy with corticosteroids in the range of 6 mg of dexamethasone (or equivalent) per day likely has a positive effect in patients requiring mechanical ventilation but there remains considerable doubt in patients over the age of 70, in patients with diabetes and patients with milder disease. Clinicians must consider the individual potential risks and benefits of corticosteroid in patients with COVID-19 rather than routinely using them until more data is available.</AbstractText><CopyrightInformation>© The Author(s) 2020.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Waterer</LastName><ForeName>Grant W</ForeName><Initials>GW</Initials><AffiliationInfo><Affiliation>University of Western Australia, Perth, Australia.</Affiliation><Identifier Source="GRID">grid.1012.2</Identifier><Identifier Source="ISNI">0000 0004 1936 7910</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>Northwestern University, Chicago, IL USA.</Affiliation><Identifier Source="GRID">grid.16753.36</Identifier><Identifier Source="ISNI">0000 0001 2299 3507</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rello</LastName><ForeName>Jordi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomedica en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.</Affiliation><Identifier Source="GRID">grid.413448.e</Identifier><Identifier Source="ISNI">0000 0000 9314 1427</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain.</Affiliation><Identifier Source="GRID">grid.430994.3</Identifier><Identifier Source="ISNI">0000 0004 1763 0287</Identifier></AffiliationInfo><AffiliationInfo><Affiliation>Clinical Research, CHU Nîmes, Université Montpellier-Nîmes, Nîmes, France.</Affiliation><Identifier Source="GRID">grid.411165.6</Identifier><Identifier Source="ISNI">0000 0004 0593 8241</Identifier></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>09</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>New Zealand</Country><MedlineTA>Infect Dis Ther</MedlineTA><NlmUniqueID>101634499</NlmUniqueID><ISSNLinking>2193-6382</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ARDS</Keyword><Keyword MajorTopicYN="N">Coronavirus</Keyword><Keyword MajorTopicYN="N">Covid-19</Keyword><Keyword MajorTopicYN="N">Pneumonia</Keyword><Keyword MajorTopicYN="N">Precision medicine</Keyword><Keyword MajorTopicYN="N">RCT</Keyword><Keyword MajorTopicYN="N">SARS</Keyword><Keyword MajorTopicYN="N">Therapy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>08</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>21</Day><Hour>6</Hour><Minute>13</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32953385</ArticleId><ArticleId IdType="doi">10.1007/s40121-020-00338-x</ArticleId><ArticleId IdType="pii">338</ArticleId><ArticleId IdType="pmc">PMC7492684</ArticleId></ArticleIdList><pmc-dir>pmcsd</pmc-dir>
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